{"id":38323,"date":"2016-12-01T10:00:00","date_gmt":"2016-12-01T09:00:00","guid":{"rendered":"https:\/\/www.fsyc.org\/?post_type=dlp_document&#038;p=38323"},"modified":"2026-10-19T12:36:17","modified_gmt":"2026-10-19T10:36:17","slug":"cocaine-addiction-is-associated-with-abnormal-prefrontal-function-increased-striatal-connectivity-and-sensitivity-to-monetary-incentives-and-decreased-connectivity-outside-the-human-reward-circuit","status":"publish","type":"dlp_document","link":"https:\/\/www.fsyc.org\/ca\/document\/cocaine-addiction-is-associated-with-abnormal-prefrontal-function-increased-striatal-connectivity-and-sensitivity-to-monetary-incentives-and-decreased-connectivity-outside-the-human-reward-circuit\/","title":{"rendered":"Cocaine addiction is associated with abnormal prefrontal function, increased striatal connectivity and sensitivity to monetary incentives, and decreased connectivity outside the human reward circuit"},"content":{"rendered":"<h3><strong>Resum del document<\/strong><\/h3>\n<p>Aquest article cient\u00edfic, publicat a la revista <em>Addiction Biology<\/em> (vol. 22, pp. 844\u2013856), estudia mitjan\u00e7ant resson\u00e0ncia magn\u00e8tica com respon el cervell de les persones amb depend\u00e8ncia de la coca\u00efna als incentius que no tenen a veure amb les drogues, en aquest cas els diners. A la recerca va participar la Fundaci\u00f3 Salut i Comunitat, juntament amb grups de l&#8217;IDIBELL, la Universitat de Barcelona, la Universitat Aut\u00f2noma de Barcelona, l&#8217;Hospital de la Santa Creu i Sant Pau i altres centres.<\/p>\n<p>L&#8217;estudi va comparar <strong>30 pacients amb depend\u00e8ncia de la coca\u00efna en abstin\u00e8ncia<\/strong> amb <strong>30 persones sanes<\/strong> de caracter\u00edstiques similars, mentre feien una tasca de loteria dins de l&#8217;esc\u00e0ner. Es van mesurar tant l&#8217;activitat cerebral (resposta BOLD davant de guanys i p\u00e8rdues de diners) com l&#8217;estructura del cervell (volum de mat\u00e8ria grisa i microestructura de la mat\u00e8ria blanca).<\/p>\n<p>Entre els principals resultats:<\/p>\n<ul>\n<li>Despr\u00e9s de rebre un incentiu econ\u00f2mic, els pacients van mostrar <strong>major activaci\u00f3 de l&#8217;estriat ventral<\/strong>, una regi\u00f3 clau del circuit de recompensa.<\/li>\n<li>A l&#8217;escor\u00e7a prefrontal es va observar un <strong>patr\u00f3 de resposta invertit<\/strong>: l&#8217;activitat era m\u00e0xima despr\u00e9s de guanys elevats i inesperats i m\u00ednima despr\u00e9s de les p\u00e8rdues, cosa que suggereix un menor control prefrontal davant dels resultats adversos.<\/li>\n<li>Els pacients presentaven <strong>m\u00e9s volum de mat\u00e8ria grisa<\/strong> al caudat i a l&#8217;escor\u00e7a orbitofrontal, i una major integritat de la mat\u00e8ria blanca a la via orbitoestriatal, per\u00f2 <strong>menor connectivitat<\/strong> als feixos d&#8217;associaci\u00f3 anteroposteriors.<\/li>\n<li>Les alteracions funcionals de l&#8217;estriat ventral es relacionaven de manera inversa amb el temps d&#8217;abstin\u00e8ncia, mentre que les alteracions estructurals no.<\/li>\n<\/ul>\n<p>Els autors conclouen que l&#8217;addicci\u00f3 a la coca\u00efna es caracteritza per una hipertr\u00f2fia i una hiperconnectivitat dins del circuit de recompensa, a costa de la connectivitat amb la resta del cervell, i per una elevada rellev\u00e0ncia de les recompenses i els c\u00e0stigs a les estructures subcorticals, amb un control prefrontal disminu\u00eft.<\/p>\n<ul>\n<li><strong>Revista:<\/strong> <em>Addiction Biology<\/em>, 22, 844\u2013856 (Society for the Study of Addiction)<\/li>\n<li><strong>Any:<\/strong> 2016 (edici\u00f3 en l\u00ednia)<\/li>\n<li><strong>DOI:<\/strong> <a href=\"https:\/\/doi.org\/10.1111\/adb.12356\" target=\"_blank\" rel=\"noopener\">10.1111\/adb.12356<\/a><\/li>\n<li><strong>Idioma:<\/strong> angl\u00e8s<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Resum del document Aquest article cient\u00edfic, publicat a la revista Addiction Biology (vol. 22, pp. 844\u2013856), estudia mitjan\u00e7ant resson\u00e0ncia magn\u00e8tica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":38297,"template":"","meta":[],"doc_categories":[2346,2350],"doc_tags":[2329,2330,2312,2322,2328],"doc_author":[2382,2383,2384,2385,2386,2387,2388,2389,2390,2352,2380,2381],"file_type":[2181],"class_list":["post-38323","dlp_document","type-dlp_document","status-publish","has-post-thumbnail","hentry","doc_categories-articles","doc_categories-publicacions-2016","doc_tags-neurociencia","doc_tags-neuroimatge","doc_tags-drogues","doc_tags-addiccions","doc_tags-cocaina","doc_author-frederic-sampedro","doc_author-jose-perez-de-los-cobos","doc_author-francesca-batlle","doc_author-josep-maria-fabregas","doc_author-joan-artur-sales","doc_author-merce-cervantes","doc_author-gerardo-lazcano","doc_author-antoni-rodriguez-fornells","doc_author-jordi-riba","doc_author-xavier-ferrer","doc_author-lucia-vaquero","doc_author-estela-camara","file_type-pdf"],"download_url":"https:\/\/www.fsyc.org\/wp-content\/uploads\/2026\/10\/Vaquero-et-al-2016_Cocaine-addiction-reward-circuit.pdf","file_size":"538 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